A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers

The phosphoinositide 3-kinase-related kinase ATR represents a central checkpoint regulator and mediator of DNA-repair. Its inhibition selectively eliminates certain subsets of cancer cells in various tumor types, but the underlying genetic determinants remain enigmatic. Here, we applied a synthetic...

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Publicat a:Oncotarget
Autors principals: Hocke, Sandra, Guo, Yang, Job, Albert, Orth, Michael, Ziesch, Andreas, Lauber, Kirsten, De Toni, Enrico N, Gress, Thomas M., Herbst, Andreas, Göke, Burkhard, Gallmeier, Eike
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872770/
https://ncbi.nlm.nih.gov/pubmed/26755646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6857
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