Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis

PURPOSE: DNA repair defects due to detrimental BRCA2-mutations confer increased susceptibility towards DNA interstrand-crosslinking (ICL) agents and define patient subpopulations for individualized genotype-based cancer therapy. However, due to the side effects of these drugs, there is a need to ide...

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Foilsithe in:Oncotarget
Main Authors: De Toni, Enrico N., Ziesch, Andreas, Rizzani, Antonia, Török, Helga-Paula, Hocke, Sandra, Lü, Shuai, Wang, Shao-Chun, Hucl, Tomas, Göke, Burkhard, Bruns, Christiane, Gallmeier, Eike
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891053/
https://ncbi.nlm.nih.gov/pubmed/26843614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7053
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