Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

BACKGROUND: Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivity towards DNA interstrand-crosslinking (ICL)-agents, F...

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Detalhes bibliográficos
Main Authors: Palagyi, Andreas, Neveling, Kornelia, Plinninger, Ursula, Ziesch, Andreas, Targosz, Bianca-Sabrina, Denk, Gerald U, Ochs, Stephanie, Rizzani, Antonia, Meier, Daniel, Thasler, Wolfgang E, Hanenberg, Helmut, De Toni, Enrico N, Bassermann, Florian, Schäfer, Claus, Göke, Burkhard, Schindler, Detlev, Gallmeier, Eike
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890608/
https://ncbi.nlm.nih.gov/pubmed/20509860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-127
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