Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to monoubiquitinate FANCD2/FANCI in response to DNA damage. Additional functions ha...

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Bibliografische gegevens
Hoofdauteurs: Pulliam-Leath, Anna C., Ciccone, Samantha L., Nalepa, Grzegorz, Li, Xiaxin, Si, Yue, Miravalle, Leticia, Smith, Danielle, Yuan, Jin, Li, Jingling, Anur, Praveen, Orazi, Attilio, Vance, Gail H., Yang, Feng-Chun, Hanenberg, Helmut, Bagby, Grover C., Clapp, D. Wade
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2010
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974601/
https://ncbi.nlm.nih.gov/pubmed/20606166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-240747
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