p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes

Fanconi anemia, complementation group C (FANCC)–deficient hematopoietic stem and progenitor cells are hypersensitive to a variety of inhibitory cytokines, one of which, TNFα, can induce BM failure and clonal evolution in Fancc-deficient mice. FANCC-deficient macrophages are also hypersensitive to TL...

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Detalhes bibliográficos
Main Authors: Anur, Praveen, Yates, Jane, Garbati, Michael R., Vanderwerf, Scott, Keeble, Winifred, Rathbun, Keaney, Hays, Laura E., Tyner, Jeffrey W., Svahn, Johanna, Cappelli, Enrico, Dufour, Carlo, Bagby, Grover C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311243/
https://ncbi.nlm.nih.gov/pubmed/22234699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-354647
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