FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines. One of these, tumor necrosis factor α (TNF-α), is also overproduced by FA mononuclear phagocytes in response to certain Toll-like receptor (TLR) agonists...

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Detalhes bibliográficos
Main Authors: Garbati, Michael R., Hays, Laura E., Keeble, Winifred, Yates, Jane E., Rathbun, R. Keaney, Bagby, Grover C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Red Cells, Iron, and Erythropoisis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814736/
https://ncbi.nlm.nih.gov/pubmed/24046015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-484816
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