Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to monoubiquitinate FANCD2/FANCI in response to DNA damage. Additional functions ha...

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Hlavní autoři: Pulliam-Leath, Anna C., Ciccone, Samantha L., Nalepa, Grzegorz, Li, Xiaxin, Si, Yue, Miravalle, Leticia, Smith, Danielle, Yuan, Jin, Li, Jingling, Anur, Praveen, Orazi, Attilio, Vance, Gail H., Yang, Feng-Chun, Hanenberg, Helmut, Bagby, Grover C., Clapp, D. Wade
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974601/
https://ncbi.nlm.nih.gov/pubmed/20606166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-240747
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