Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis

We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, ce...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Guo, Yang, Ziesch, Andreas, Hocke, Sandra, Kampmann, Eric, Ochs, Stephanie, De Toni, Enrico N, Göke, Burkhard, Gallmeier, Eike
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407596/
https://ncbi.nlm.nih.gov/pubmed/25331547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12444
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