The POLD1(R689W) variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors

Inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in certain tumors. As previously shown, this is at least partly attributable to synthetic lethal interactions between ATR and POLD1, the catalytic subunit of the polymerase δ. Various POL...

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Vydáno v:Sci Rep
Hlavní autoři: Job, Albert, Tatura, Marina, Schäfer, Cora, Lutz, Veronika, Schneider, Hanna, Lankat-Buttgereit, Brigitte, Zielinski, Alexandra, Borgmann, Kerstin, Bauer, Christian, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641191/
https://ncbi.nlm.nih.gov/pubmed/33144657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76033-1
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