Endogenous IGFBP-3 Regulates Excess Collagen Expression in Intestinal Smooth Muscle Cells of Crohn’s Disease Strictures

BACKGROUND: Stricture formation occurs in ≈30% of patients with Crohn’s disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, inc...

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Vydáno v:Inflamm Bowel Dis
Hlavní autoři: Flynn, Robert S., Mahavadi, Sunila, Murthy, Karnam S., Grider, John R., Kellum, John M., Akbari, Homayoon, Kuemmerle, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863983/
https://ncbi.nlm.nih.gov/pubmed/20848532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21351
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