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Endogenous IGF-I and αVβ3 Integrin Ligands Regulate the Increased Smooth Muscle Hyperplasia of Stricturing Crohn's Disease
BACKGROUND/AIMS: Insulin-like growth factor-I (IGF-I) regulates human intestinal smooth muscle growth by stimulating proliferation and inhibiting apoptosis. IGF-I-stimulated growth is augmented when αvβ3 integrin is occupied by its ligands, fibronectin and vitronectin. Increased IGF-I expression and...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813387/ https://ncbi.nlm.nih.gov/pubmed/19751734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.09.003 |
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