Endogenous IGF-I and αVβ3 Integrin Ligands Regulate the Increased Smooth Muscle Hyperplasia of Stricturing Crohn's Disease

BACKGROUND/AIMS: Insulin-like growth factor-I (IGF-I) regulates human intestinal smooth muscle growth by stimulating proliferation and inhibiting apoptosis. IGF-I-stimulated growth is augmented when αvβ3 integrin is occupied by its ligands, fibronectin and vitronectin. Increased IGF-I expression and...

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Hauptverfasser: Flynn, Robert S., Murthy, Karnam S., Grider, John R., Kellum, John M., Kuemmerle, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813387/
https://ncbi.nlm.nih.gov/pubmed/19751734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.09.003
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