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Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/−) mice
BACKGROUND & AIMS: Strictures occur in ~30% of patients with Crohn’s disease and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. Insulin-like Growth Factor-I (IGF-I) expression is increased in...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2990779/ https://ncbi.nlm.nih.gov/pubmed/20722057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21437 |
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