Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/−) mice

BACKGROUND & AIMS: Strictures occur in ~30% of patients with Crohn’s disease and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. Insulin-like Growth Factor-I (IGF-I) expression is increased in...

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Autori principali: Mahavadi, Sunila, Flynn, Robert S., Grider, John R., Qiao, Liya, Murthy, Karnam S., Hazelgrove, Krystina B., Kuemmerle, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990779/
https://ncbi.nlm.nih.gov/pubmed/20722057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21437
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