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Endogenous IGFBP-3 Regulates Excess Collagen Expression in Intestinal Smooth Muscle Cells of Crohn’s Disease Strictures
BACKGROUND: Stricture formation occurs in ≈30% of patients with Crohn’s disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, inc...
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| Publicado en: | Inflamm Bowel Dis |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4863983/ https://ncbi.nlm.nih.gov/pubmed/20848532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21351 |
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