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Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohn’s Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide
BACKGROUND: Strictures develop in >30% of Crohn’s disease. No available medication prevents stricture development in susceptible patients. In Crohn’s strictures, but not adjacent normal intestine, TGF-β1 increases in muscularis smooth muscle, increasing collagen I production and strictures. Muscl...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889641/ https://ncbi.nlm.nih.gov/pubmed/24051933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0b013e3182a8452e |
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