Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohn’s Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

BACKGROUND: Strictures develop in >30% of Crohn’s disease. No available medication prevents stricture development in susceptible patients. In Crohn’s strictures, but not adjacent normal intestine, TGF-β1 increases in muscularis smooth muscle, increasing collagen I production and strictures. Muscl...

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Main Authors: Li, Chao, Flynn, Robert S., Grider, John R., Murthy, Karnam S., Kellum, John M., Akbari, Homayoon, Kuemmerle, John F.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889641/
https://ncbi.nlm.nih.gov/pubmed/24051933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0b013e3182a8452e
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