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Non-canonical STAT3 activation regulates excess TGF-β1 and Collagen I expression in muscle of stricturing Crohn's disease
BACKGROUND & AIMS: Increased TGF-β1 and TGF-β1-dependent Collagen I production in intestinal mesenchymal muscle cells result in fibrosis in patients with Montreal B2 fibrostenotic Crohn's disease. Numerous cytokines, including IL-6, are produced by activated mesenchymal cells themselves and...
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| Publié dans: | J Immunol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369432/ https://ncbi.nlm.nih.gov/pubmed/25740948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401779 |
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