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Non-canonical STAT3 activation regulates excess TGF-β1 and Collagen I expression in muscle of stricturing Crohn's disease

BACKGROUND & AIMS: Increased TGF-β1 and TGF-β1-dependent Collagen I production in intestinal mesenchymal muscle cells result in fibrosis in patients with Montreal B2 fibrostenotic Crohn's disease. Numerous cytokines, including IL-6, are produced by activated mesenchymal cells themselves and...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Li, Chao, Iness, Audra, Yoon, Jennifer, Grider, John R., Murthy, Karnam S., Kellum, John M., Kuemmerle, John F.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369432/
https://ncbi.nlm.nih.gov/pubmed/25740948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401779
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