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Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam

The aim of this study was to determine aztreonam (ATM) membrane permeability using Calu-3 cells and its plasma and pulmonary epithelial lining fluid (ELF) pharmacokinetics in rats after intratracheal nebulization and intravenous administration (15 mg · kg(−1)). ATM exhibits low Calu-3 permeability (...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Marchand, Sandrine, Grégoire, Nicolas, Brillault, Julien, Lamarche, Isabelle, Gobin, Patrice, Couet, William
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862445/
https://ncbi.nlm.nih.gov/pubmed/26926626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00165-16
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