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Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam
The aim of this study was to determine aztreonam (ATM) membrane permeability using Calu-3 cells and its plasma and pulmonary epithelial lining fluid (ELF) pharmacokinetics in rats after intratracheal nebulization and intravenous administration (15 mg · kg(−1)). ATM exhibits low Calu-3 permeability (...
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| Publicado en: | Antimicrob Agents Chemother |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4862445/ https://ncbi.nlm.nih.gov/pubmed/26926626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00165-16 |
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