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Conformational Dynamics and Allostery in Pyruvate Kinase

Pyruvate kinase catalyzes the final step in glycolysis and is allosterically regulated to control flux through the pathway. Two models are proposed to explain how Escherichia coli pyruvate kinase type 1 is allosterically regulated: the “domain rotation model” suggests that both the domains within th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Donovan, Katherine A., Zhu, Shaolong, Liuni, Peter, Peng, Fen, Kessans, Sarah A., Wilson, Derek J., Dobson, Renwick C. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861489/
https://ncbi.nlm.nih.gov/pubmed/26879751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676270
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