Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation

Allostery and covalent modification are major means of fast-acting metabolic regulation. Their relative roles in responding to environmental changes remain, however, unclear. Here we examine this issue, using as a case study the rapid decrease in pyruvate kinase flux in yeast upon glucose removal. T...

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Bibliografiske detaljer
Main Authors: Xu, Yi-Fan, Zhao, Xin, Glass, David S., Absalan, Farnaz, Perlman, David H., Broach, James R., Rabinowitz, Joshua D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472130/
https://ncbi.nlm.nih.gov/pubmed/22902555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.07.013
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