Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Drugs that allosterically target the human calcium-sensing receptor (CaSR) have substantial therapeutic potential, but are currently limited. Given the absence of high-resolution structures of the CaSR, we combined mutagenesis with a novel analytical approach and molecular modeling to develop an “en...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Res
Hauptverfasser: Leach, Katie, Gregory, Karen J, Kufareva, Irina, Khajehali, Elham, Cook, Anna E, Abagyan, Ruben, Conigrave, Arthur D, Sexton, Patrick M, Christopoulos, Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856764/
https://ncbi.nlm.nih.gov/pubmed/27002221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.36
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