Pathologic Endoplasmic Reticulum Stress Mediated by the IRE1 Pathway Contributes to Pre-insulitic Beta Cell Apoptosis in a Virus Induced Rat Model of Type 1 Diabetes

AIMS/HYPOTHESIS: We hypothesized that pathologic ER stress contributes to beta cell death during development of type 1 diabetes. In this study, we investigated the occurrence of beta cell ER stress and the signaling pathways involved during discrete stages of autoimmune diabetes progression. The vir...

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Vydáno v:Diabetologia
Hlavní autoři: Yang, Chaoxing, diIorio, Philip, Jurczyk, Agata, O'Sullivan-Murphy, Bryan, Urano, Fumihiko, Bortell, Rita
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845659/
https://ncbi.nlm.nih.gov/pubmed/24121653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-3044-4
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