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IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions
The endoplasmic reticulum (ER) has emerged as a critical regulator of cell fate. IRE1 is a transmembrane protein with kinase and RNase activities that is localized to the ER and that promotes resistance to ER stress. Here we showed a mechanism by which IRE1 conferred protection against ER stress-med...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492519/ https://ncbi.nlm.nih.gov/pubmed/26106220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa0341 |
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