Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin

PURPOSE: Dipeptidyl-peptidase-4 (DPP-4) inhibitors are known to increase insulin secretion and beta cell proliferation in rodents. To investigate the effects on human beta cells in vivo, we utilize immunodeficient mice transplanted with human islets. The study goal was to determine the efficacy of a...

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Bibliografiske detaljer
Main Authors: Jurczyk, Agata, diIorio, Philip, Brostowin, Dean, Leehy, Linda, Yang, Chaoxing, Urano, Fumihiko, Harlan, David M, Shultz, Leonard D, Greiner, Dale L, Bortell, Rita
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864939/
https://ncbi.nlm.nih.gov/pubmed/24376359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S53154
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