Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin

PURPOSE: Dipeptidyl-peptidase-4 (DPP-4) inhibitors are known to increase insulin secretion and beta cell proliferation in rodents. To investigate the effects on human beta cells in vivo, we utilize immunodeficient mice transplanted with human islets. The study goal was to determine the efficacy of a...

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Autores principales: Jurczyk, Agata, diIorio, Philip, Brostowin, Dean, Leehy, Linda, Yang, Chaoxing, Urano, Fumihiko, Harlan, David M, Shultz, Leonard D, Greiner, Dale L, Bortell, Rita
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2013
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864939/
https://ncbi.nlm.nih.gov/pubmed/24376359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S53154
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