Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg(null) RIP-DTR mice engrafted with human islets

OBJECTIVE: Glucagon-like peptide-1 induces glucose-dependent insulin secretion and, in rodents, increases proliferation and survival of pancreatic beta cells. To investigate the effects on human beta cells, we used immunodeficient mice transplanted with human islets. The goal was to determine whethe...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Diabetes Metab Syndr Obes
Main Authors: Yang, Chaoxing, Loehn, Matthias, Jurczyk, Agata, Przewozniak, Natalia, Leehy, Linda, Herrera, Pedro L, Shultz, Leonard D, Greiner, Dale L, Harlan, David M, Bortell, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548726/
https://ncbi.nlm.nih.gov/pubmed/26316789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S87253
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados