CHOP Mediates Endoplasmic Reticulum Stress-Induced Apoptosis in Gimap5-Deficient T Cells

Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap5 gene that leads to spontaneous apoptosis o...

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Détails bibliographiques
Auteurs principaux: Pino, Steven C., O'Sullivan-Murphy, Bryan, Lidstone, Erich A., Yang, Chaoxing, Lipson, Kathryn L., Jurczyk, Agata, diIorio, Philip, Brehm, Michael A., Mordes, John P., Greiner, Dale L., Rossini, Aldo A., Bortell, Rita
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674944/
https://ncbi.nlm.nih.gov/pubmed/19424493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005468
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