Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding

In prokaryotic systems, the initiation phase of protein synthesis is governed by the presence of initiation factors that guide the transition of the small ribosomal subunit (30S) from an unlocked preinitiation complex (30S preIC) to a locked initiation complex (30SIC) upon the formation of a correct...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Fabbretti, Attilio, Schedlbauer, Andreas, Brandi, Letizia, Kaminishi, Tatsuya, Giuliodori, Anna Maria, Garofalo, Raffaella, Ochoa-Lizarralde, Borja, Takemoto, Chie, Yokoyama, Shigeyuki, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843482/
https://ncbi.nlm.nih.gov/pubmed/27071098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521156113
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