Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding

In prokaryotic systems, the initiation phase of protein synthesis is governed by the presence of initiation factors that guide the transition of the small ribosomal subunit (30S) from an unlocked preinitiation complex (30S preIC) to a locked initiation complex (30SIC) upon the formation of a correct...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fabbretti, Attilio, Schedlbauer, Andreas, Brandi, Letizia, Kaminishi, Tatsuya, Giuliodori, Anna Maria, Garofalo, Raffaella, Ochoa-Lizarralde, Borja, Takemoto, Chie, Yokoyama, Shigeyuki, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843482/
https://ncbi.nlm.nih.gov/pubmed/27071098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521156113
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