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Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A
Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4787777/ https://ncbi.nlm.nih.gov/pubmed/26464437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv975 |
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