Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A

Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa-Lizarralde, Borja, He, Cheng-Guang, Milón, Pohl, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787777/
https://ncbi.nlm.nih.gov/pubmed/26464437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv975
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