Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A

Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa-Lizarralde, Borja, He, Cheng-Guang, Milón, Pohl, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787777/
https://ncbi.nlm.nih.gov/pubmed/26464437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv975
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