Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A

Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa-Lizarralde, Borja, He, Cheng-Guang, Milón, Pohl, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787777/
https://ncbi.nlm.nih.gov/pubmed/26464437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv975
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