A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

ABSTRACT The initiation phase is the rate-limiting step of protein synthesis (translation) and is finely regulated, making it an important drug target. In bacteria, initiation is guided by three initiation factors and involves positioning the start site on the messenger RNA within the P-site on the...

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Main Authors: Andreas Schedlbauer, Xu Han, Wouter van Bakel, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Idoia Iturrioz, Retina Çapuni, Ransford Parry, Ronny Zegarra, David Gil-Carton, Jorge P. López-Alonso, Kristina Barragan Sanz, Letizia Brandi, Claudio O. Gualerzi, Paola Fucini, Sean R. Connell
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2025-11-01
Serija:mBio
Teme:
cryo-electron microscopy
cryo-EM
antibiotic
ribosome
GE81112
initiation
Online dostop:https://journals.asm.org/doi/10.1128/mbio.03978-24
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