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Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer
Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during misfolding. Here we studied the structural con...
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| Udgivet i: | Protein Sci |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838641/ https://ncbi.nlm.nih.gov/pubmed/26940799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2911 |
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