Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during misfolding. Here we studied the structural con...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Akoury, Elias, Mukrasch, Marco D., Biernat, Jacek, Tepper, Katharina, Ozenne, Valery, Mandelkow, Eckhard, Blackledge, Martin, Zweckstetter, Markus
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838641/
https://ncbi.nlm.nih.gov/pubmed/26940799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2911
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