Suramin inhibits cullin-RING E3 ubiquitin ligases

Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the recruitment of the E2 ubiquitin-conjugating enzyme Cdc34 through electrostatic interactions between E3′s cullin conserved b...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Wu, Kenneth, Chong, Robert A., Yu, Qing, Bai, Jin, Spratt, Donald E., Ching, Kevin, Lee, Chan, Miao, Haibin, Tappin, Inger, Hurwitz, Jerard, Zheng, Ning, Shaw, Gary S., Sun, Yi, Felsenfeld, Dan P., Sanchez, Roberto, Zheng, Jun-nian, Pan, Zhen-Qiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833235/
https://ncbi.nlm.nih.gov/pubmed/27001857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601089113
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