Suramin inhibits cullin-RING E3 ubiquitin ligases

Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the recruitment of the E2 ubiquitin-conjugating enzyme Cdc34 through electrostatic interactions between E3′s cullin conserved b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Wu, Kenneth, Chong, Robert A., Yu, Qing, Bai, Jin, Spratt, Donald E., Ching, Kevin, Lee, Chan, Miao, Haibin, Tappin, Inger, Hurwitz, Jerard, Zheng, Ning, Shaw, Gary S., Sun, Yi, Felsenfeld, Dan P., Sanchez, Roberto, Zheng, Jun-nian, Pan, Zhen-Qiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833235/
https://ncbi.nlm.nih.gov/pubmed/27001857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601089113
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