Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states(1,2). Healthy metazoan cells effectively eliminate intracellular protein aggregates(3,4), indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazo...

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Publicado en:Nature
Main Authors: Nillegoda, Nadinath B., Kirstein, Janine, Szlachcic, Anna, Berynskyy, Mykhaylo, Stank, Antonia, Stengel, Florian, Arnsburg, Kristin, Gao, Xuechao, Scior, Annika, Aebersold, Ruedi, Guilbride, D. Lys, Wade, Rebecca C., Morimoto, Richard I., Mayer, Matthias P., Bukau, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830470/
https://ncbi.nlm.nih.gov/pubmed/26245380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14884
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