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Metazoan Hsp70-based protein disaggregases: emergence and mechanisms
Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing misfolded proteins to form aggregates, which dedicated molecular machines have evolved to solubilize. In bacteria, fungi, protozoa and plants protein disaggregation involves an Hsp70•J-protein chaperone system,...
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| 出版年: | Front Mol Biosci |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598581/ https://ncbi.nlm.nih.gov/pubmed/26501065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2015.00057 |
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