Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

Intracellular amyloid fibrils linked to neurodegenerative disease typically accumulate in an age-related manner, suggesting inherent cellular capacity for counteracting amyloid formation in early life. Metazoan molecular chaperones assist native folding and block polymerization of amyloidogenic prot...

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Udgivet i:Mol Cell
Main Authors: Gao, Xuechao, Carroni, Marta, Nussbaum-Krammer, Carmen, Mogk, Axel, Nillegoda, Nadinath B., Szlachcic, Anna, Guilbride, D. Lys, Saibil, Helen R., Mayer, Matthias P., Bukau, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072489/
https://ncbi.nlm.nih.gov/pubmed/26300264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.012
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