Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

Refolding aggregated proteins is essential in combating cellular proteotoxic stress. Together with Hsp70, Hsp100 chaperones, including Escherichia coli ClpB, form a powerful disaggregation machine that threads aggregated polypeptides through the central pore of tandem adenosine triphosphatase (ATPas...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Deville, Célia, Carroni, Marta, Franke, Kamila B., Topf, Maya, Bukau, Bernd, Mogk, Axel, Saibil, Helen R.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544394/
https://ncbi.nlm.nih.gov/pubmed/28798962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701726
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