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Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase
The members of the hexameric AAA+ disaggregase of E. coli and S. cerevisiae, ClpB, and Hsp104, cooperate with the Hsp70 chaperone system in the solubilization of aggregated proteins. Aggregate solubilization relies on a substrate threading activity of ClpB/Hsp104 fueled by ATP hydrolysis in both ATP...
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| Publicado no: | Front Mol Biosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5319980/ https://ncbi.nlm.nih.gov/pubmed/28275610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2017.00006 |
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