Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops. Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism. We stu...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Deville, Célia, Franke, Kamila, Mogk, Axel, Bukau, Bernd, Saibil, Helen R.
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593972/
https://ncbi.nlm.nih.gov/pubmed/31216466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.075
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