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Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
Hsp100 and Hsp70 chaperones in bacteria, yeast, and plants cooperate to reactivate aggregated proteins. Disaggregation relies on Hsp70 function and on ATP-dependent threading of aggregated polypeptides through the pore of the Hsp100 AAA(+) hexamer. In yeast, both chaperones also promote propagation...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The Rockefeller University Press
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413357/ https://ncbi.nlm.nih.gov/pubmed/22869599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201074 |
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