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The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species
The accumulation and prion‐like propagation of α‐synuclein and other amyloidogenic proteins are associated with devastating neurodegenerative diseases. Metazoan heat shock protein HSP70 and its co‐chaperones DNAJB1 and HSP110 constitute a disaggregation machinery that is able to disassemble α‐synucl...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7327497/ https://ncbi.nlm.nih.gov/pubmed/32449565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103954 |
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