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Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
Accumulation of aggregation-prone misfolded proteins disrupts normal cellular function and promotes ageing and disease. Bacteria, fungi and plants counteract this by solubilizing and refolding aggregated proteins via a powerful cytosolic ATP-dependent bichaperone system, comprising the AAA+ disaggre...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
European Molecular Biology Organization
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492728/ https://ncbi.nlm.nih.gov/pubmed/22990239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.264 |
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