Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states(1,2). Healthy metazoan cells effectively eliminate intracellular protein aggregates(3,4), indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazo...

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Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Nillegoda, Nadinath B., Kirstein, Janine, Szlachcic, Anna, Berynskyy, Mykhaylo, Stank, Antonia, Stengel, Florian, Arnsburg, Kristin, Gao, Xuechao, Scior, Annika, Aebersold, Ruedi, Guilbride, D. Lys, Wade, Rebecca C., Morimoto, Richard I., Mayer, Matthias P., Bukau, Bernd
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830470/
https://ncbi.nlm.nih.gov/pubmed/26245380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14884
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