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Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation
Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states(1,2). Healthy metazoan cells effectively eliminate intracellular protein aggregates(3,4), indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazo...
Shranjeno v:
| izdano v: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830470/ https://ncbi.nlm.nih.gov/pubmed/26245380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14884 |
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