Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states(1,2). Healthy metazoan cells effectively eliminate intracellular protein aggregates(3,4), indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazo...

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Vydáno v:Nature
Hlavní autoři: Nillegoda, Nadinath B., Kirstein, Janine, Szlachcic, Anna, Berynskyy, Mykhaylo, Stank, Antonia, Stengel, Florian, Arnsburg, Kristin, Gao, Xuechao, Scior, Annika, Aebersold, Ruedi, Guilbride, D. Lys, Wade, Rebecca C., Morimoto, Richard I., Mayer, Matthias P., Bukau, Bernd
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830470/
https://ncbi.nlm.nih.gov/pubmed/26245380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14884
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