Crucial HSP70 co–chaperone complex unlocks metazoan protein disaggregation

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states(1,2). Healthy metazoan cells effectively eliminate intracellular protein aggregates(3,4), indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazo...

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Publicado en:Nature
Autores principales: Nillegoda, Nadinath B., Kirstein, Janine, Szlachcic, Anna, Berynskyy, Mykhaylo, Stank, Antonia, Stengel, Florian, Arnsburg, Kristin, Gao, Xuechao, Scior, Annika, Aebersold, Ruedi, Guilbride, D. Lys, Wade, Rebecca C., Morimoto, Richard I., Mayer, Matthias P., Bukau, Bernd
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830470/
https://ncbi.nlm.nih.gov/pubmed/26245380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14884
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