In vivo properties of the disaggregase function of J‐proteins and Hsc70 in Caenorhabditis elegans stress and aging

Protein aggregation is enhanced upon exposure to various stress conditions and aging, which suggests that the quality control machinery regulating protein homeostasis could exhibit varied capacities in different stages of organismal lifespan. Recently, an efficient metazoan disaggregase activity was...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Kirstein, Janine, Arnsburg, Kristin, Scior, Annika, Szlachcic, Anna, Guilbride, D. Lys, Morimoto, Richard I., Bukau, Bernd, Nillegoda, Nadinath B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676055/
https://ncbi.nlm.nih.gov/pubmed/29024389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12686
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