In vivo properties of the disaggregase function of J‐proteins and Hsc70 in Caenorhabditis elegans stress and aging

Protein aggregation is enhanced upon exposure to various stress conditions and aging, which suggests that the quality control machinery regulating protein homeostasis could exhibit varied capacities in different stages of organismal lifespan. Recently, an efficient metazoan disaggregase activity was...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Kirstein, Janine, Arnsburg, Kristin, Scior, Annika, Szlachcic, Anna, Guilbride, D. Lys, Morimoto, Richard I., Bukau, Bernd, Nillegoda, Nadinath B.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676055/
https://ncbi.nlm.nih.gov/pubmed/29024389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12686
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