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Metazoan Hsp70-based protein disaggregases: emergence and mechanisms
Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing misfolded proteins to form aggregates, which dedicated molecular machines have evolved to solubilize. In bacteria, fungi, protozoa and plants protein disaggregation involves an Hsp70•J-protein chaperone system,...
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| Veröffentlicht in: | Front Mol Biosci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598581/ https://ncbi.nlm.nih.gov/pubmed/26501065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2015.00057 |
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