Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these pumps important antibacterial drug discovery...

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保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Sjuts, Hanno, Vargiu, Attilio V., Kwasny, Steven M., Nguyen, Son T., Kim, Hong-Suk, Ding, Xiaoyuan, Ornik, Alina R., Ruggerone, Paolo, Bowlin, Terry L., Nikaido, Hiroshi, Pos, Klaas M., Opperman, Timothy J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2016
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822567/
https://ncbi.nlm.nih.gov/pubmed/26976576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602472113
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