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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these pumps important antibacterial drug discovery...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822567/ https://ncbi.nlm.nih.gov/pubmed/26976576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602472113 |
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