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Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays
BACKGROUND: The Resistance-Nodulation-Division (RND) family transporter AcrB plays a major role in the intrinsic and increased resistance of Escherichia coli to a large number of antibiotics. The distal binding pocket within this multidrug efflux transporter is very large, but the effort to define t...
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| Veröffentlicht in: | Biochem Biophys Res Commun |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137507/ https://ncbi.nlm.nih.gov/pubmed/27789287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.10.083 |
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